Author

Sean McFadyen

Massey UniversityORCID 0009-0005-0863-159XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:Drosophila· 3 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:development & morphogenesis· 2 Approach:genetic perturbation / CRISPR· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Approach:comparative / phylogenetic analysis· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Elizabeth A. OstrowskiiD· 3 shared Mische HollandiD· 2 shared Tera C. LeviniD· 2 shared Cathleen M.E. Broersma· 1 shared Cathleen M.E. BroersmaiD· 1 shared Courtney MastersoniD· 1 shared Fabiola Medina· 1 shared Hui Hui PhuaiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersEvolutionary Biology

Elizabeth A. OstrowskiORCID

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3 papers

Recent·Most cited

Evolutionary BiologyProceedings of the National Academy of SciencesPeer-reviewedDec 16, 2025

Hypermutable hotspot enables the rapid evolution of self/non-self recognition genes in Dictyostelium

Mische Holland, M.W. Ahmed, Janet M. Young…·Tera C. Levin

The paper investigates the rapid evolution of self/non-self recognition genes in Dictyostelium by analyzing genome sequences and identifying a hypermutable hotspot in the tgrBC locus.

5 citations

Drosophilawhole-genome sequencing

𝕏 PostBluesky

Evolutionary BiologybioRxivPreprintOct 22, 2025

Evolutionary dynamics of the tgr gene family in Dictyostelium allows escape from Crozier's Paradox

Rafael Prieto, Sean McFadyen, Fabiola Medina…·Elizabeth A. Ostrowski

The paper examines Crozier's Paradox in Dictyostelium discoideum by analyzing tgrB1 and tgrC1 genes, finding no strong evidence for the paradox and suggesting recombination generates genetic variation.

DOI 10.1101/2025.10.22.684067

DrosophilaDNA methylation

𝕏 PostBluesky

Evolutionary BiologybioRxivPreprintJul 16, 2024

Natural variation in fruiting body morphology in the amoeba Dictyostelium discoideum

Cathleen M.E. Broersma, Sean McFadyen, Elizabeth A. Ostrowski

The paper examines variation in fruiting body morphology and stalk investment in natural populations of Dictyostelium discoideum, finding differences in altruism investment across populations and scales.

DOI 10.1101/2024.07.16.603515

Drosophilaexperimental assay

𝕏 PostBluesky