Sean P. David

The Contribution of Pharmacogenetic Drug Interactions to 90-Day Hospital Readmissions: Preliminary Results from a Real-World Healthcare System

This study examines the association between pharmacogenetic drug interactions and 90-day hospital readmissions, finding a 33% increased risk after adjusting for demographic and clinical factors.

Whole-Genome Association Analyses of Sleep-disordered Breathing Phenotypes in the NHLBI TOPMed Program

The paper reports whole-genome association analyses of sleep-disordered breathing traits in the NHLBI TOPMed program, identifying rare and common variant associations.

Implementing Primary Care Mediated Population Genetic Screening within an Integrated Health System

This study evaluates a population genetic screening program mediated by primary care physicians, finding actionable variants in nearly 8% of patients and suggesting its potential to improve preventative care.

Genome Sequencing Unveils a New Regulatory Landscape of Platelet Reactivity

The paper uses whole genome sequencing to identify genetic loci associated with platelet aggregation, including novel variants in RGS18, SVEP1, and PEAR1.

Exome chip meta-analysis elucidates the genetic architecture of rare coding variants in smoking and drinking behavior

The paper analyzes rare coding variants in smoking and drinking behavior using exome chip data, finding that they contribute to phenotypic variation but require larger samples for individual variant associations.