Author

Jeff Haessler

Fred Hutch Cancer Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 3 Genetic & Genomic Medicine· 2

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:statistical model· 5 Research Focus:GWAS / association mapping· 4 Assay:GWAS summary statistics· 2 Assay:whole-exome sequencing· 2 Approach:benchmark study· 1 Assay:bulk RNA-seq· 1 Research Focus:eQTL / molecular QTL mapping· 1

Frequent Co-Authors

Emanuele Di AngelantonioiD· 4 shared Bruce M. PsatyiD· 3 shared Erwin P. BöttingeriD· 3 shared Girish N. NadkarniiD· 3 shared Jean‐Claude TardifiD· 3 shared Jennifer A. BrodyiD· 3 shared Jette Bork‐JenseniD· 3 shared Joanna M. M. HowsoniD· 3 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersGenetics

Emanuele Di AngelantonioORCID

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Author profile →

5 papers

Recent·Most cited

Cross-Ancestry Investigation of Venous Thromboembolism Genomic Predictors

Florian Thibord, Derek M. Klarin, Jennifer A. Brody, Ming‐Huei Chen, Michael G. Levin, Daniel I. Chasman, Ellen L. Goode, Kristian Hveem, Maris Teder‐Laving, Ángel Martínez-Pérez, Dylan Aïssi, Delphine Daian-Bacq, Kaoru Ito, Pradeep Natarajan, Pamela L. Lutsey, , Nicholas L. Smith

This study identifies 135 genomic loci associated with venous thromboembolism risk through cross-ancestry GWAS and provides insights into biological pathways and potential therapeutic targets.

Circulation · Oct 17, 2022Peer-reviewedGenetic & Genomic Medicine

Trans-ethnic and ancestry-specific blood-cell genetics in 746,667 individuals from 5 global populations

Ming‐Huei Chen, Laura M. Raffield, Abdou Mousas, Saori Sakaue, Jennifer E. Huffman, Arden Moscati, Bhavi Trivedi, Tao Jiang, Parsa Akbari, Dragana Vuckovic, Erik L. Bao, Xue Yun Zhong, Regina Manansala, Véronique Laplante, Minhui Chen, , Ruth J. F. Loos

This study identifies 5,552 blood-cell trait-variant associations across 746,667 individuals from 5 global populations, including 71 novel loci and ancestry-specific variants not found in European ancestry populations.

Cell · Sep 1, 2020Peer-reviewedGenetics

The Polygenic and Monogenic Basis of Blood Traits and Diseases

Dragana Vuckovic, Erik L. Bao, Parsa Akbari, Caleb A. Lareau, Abdou Mousas, Tao Jiang, Ming‐Huei Chen, Laura M. Raffield, Manuel Tardáguila, Jennifer E. Huffman, Scott C. Ritchie, Karyn Mégy, Hannes Ponstingl, Christopher J. Penkett, Patrick K. Albers, , Εvangelos Εvangelou

This study identifies 5,106 new genetic variants associated with blood cell traits using large-scale GWAS, highlighting the polygenic and monogenic basis of hematopoiesis.

Cell · Sep 1, 2020Peer-reviewedGenetic & Genomic Medicine

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

Anne E. Justice, Tugce Karaderi, Heather M. Highland, Kristin L. Young, Mariaelisa Graff, Yingchang Lu, Valérie Turcot, Paul Livermore Auer, Rebecca S. Fine, Xiuqing Guo, Claudia Schurmann, Adelheid M. Lempradl, Eirini Marouli, Anubha Mahajan, Thomas W. Winkler, , Andrew Tym Hattersley

This study identifies 15 common and 9 low-frequency protein-coding variants associated with body fat distribution, implicating novel genes related to lipid homeostasis and type 2 diabetes.

Nature Genetics · Feb 18, 2019Peer-reviewedGenetics

Exome chip meta-analysis elucidates the genetic architecture of rare coding variants in smoking and drinking behavior

David M. Brazel, Yu Jiang, Jordan M. Hughey, Valérie Turcot, Xiaowei Zhan, Jian Gong, Chiara Batini, J. Dylan Weissenkampen, Mengzhen Liu, Daniel R. Barnes, Sarah E. Bertelsen, Yi‐Ling Chou, Abdullah Mesut Erzurumluoglu, Jessica D. Faul, Jeff Haessler, , Jean Ferrières

The paper analyzes rare coding variants in smoking and drinking behavior using exome chip data, finding that they contribute to phenotypic variation but require larger samples for individual variant associations.

Biological Psychiatry · Dec 6, 2018Peer-reviewedGenetics