Xue Yun Zhong

scCotag: Diagonal integration of single-cell multi-omics data via prior-informed co-optimal transport and regularized barycentric mapping

scCotag improves single-cell multi-omics integration by using co-optimal transport and regularized barycentric mapping, outperforming existing methods in alignment and embedding accuracy.

A genetics-guided integrative framework for drug repurposing: identifying antihypertensive drug telmisartan for type 2 diabetes

This study develops a genetics-informed framework to repurpose drugs for type 2 diabetes, identifying telmisartan as a potential treatment based on GWAS data and EHR validation.

Genome-wide association meta-analysis identifies novel ancestry-specific primary open-angle glaucoma loci and shared biology with vascular mechanisms and cell proliferation

This study identifies ancestry-specific and sex-specific genetic loci for primary open-angle glaucoma through a meta-analysis of 15 biobanks, highlighting shared biology with vascular mechanisms and cell proliferation.

Global Biobank Meta-analysis Initiative: powering genetic discovery across human diseases

Meta-analysis of harmonized GWAS from up to 18 biobanks (six ancestry groups) across 14 endpoints replicated 320 known loci and identified 188 apparently novel loci.

Genome Sequencing Unveils a New Regulatory Landscape of Platelet Reactivity

The paper uses whole genome sequencing to identify genetic loci associated with platelet aggregation, including novel variants in RGS18, SVEP1, and PEAR1.