Arnaud Liehrmann

phyloDS identifies differentially used orthologous splice junctions across species by improving orthology definition, statistical testing, and sequence-level validation.

This paper introduces phyloDE, a method for interspecies differential gene expression analysis that controls FDR and identifies more DE genes with consistent cis-regulatory changes.

ProteoCast predicts the functional impact of missense variants using evolutionary information, achieving high accuracy across the Drosophila proteome.

This study investigates the role of the GT1 domain in Arabidopsis RNase J by showing it binds dsRNA and DNA, affects enzyme solubility, and is critical for dsRNA removal in plastids.

ProteoCast predicts and interprets missense variant effects using evolutionary and structural analysis, achieving high accuracy in pathogenicity prediction and identifying functional motifs in disordered regions.

DiffSegR identifies differentially expressed regions in RNA-Seq data without prior annotation by detecting changepoints in log2 fold change, revealing new insights into RNA processing.