NeurosciencebioRxivPreprint
NEK1 haploinsufficiency impairs ciliogenesis in human iPSC-derived motoneurons and brain organoids
Marta Nice Sorce, Sabrina Invernizzi, Valeria Casiraghi…·Antonia Ratti
This study shows that NEK1 haploinsufficiency in human iPSC-derived motoneurons and brain organoids impairs ciliogenesis, linking NEK1 mutations to ALS through reduced primary cilium formation.
DOI 10.1101/2024.02.29.582696