Alessio Silva

This paper introduces human myelin spheres (MyS) as a model for studying myelination and demyelination, showing their ability to form myelinated neurons and mimic in vivo oligodendrocyte development.

This study shows that NEK1 haploinsufficiency in human iPSC-derived motoneurons and brain organoids impairs ciliogenesis, linking NEK1 mutations to ALS through reduced primary cilium formation.

This study identifies defective lipid metabolism in Schwann cells as a cause of CMT1A, showing altered lipid composition and membrane dynamics in mouse models and human iPSC-derived cells.