Author

Alexander E. Gorbalenya

Leiden UniversityORCID 0000-0002-4967-7341Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Approach:comparative / phylogenetic analysis· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:phylogenetics / evolution· 1 Approach:statistical model· 1

Frequent Co-Authors

Benjamin W. NeumaniD· 2 shared Chris LauberiD· 2 shared Dmitry V. SamborskiyiD· 2 shared Alexandria Smart· 1 shared Josef Vaas· 1 shared N. E. CaliskaniD· 1 shared Nicolai Böker· 1 shared Orian GilmeriD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMicrobiology

Benjamin W. NeumanORCID

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2 papers

Recent·Most cited

A large replicase of nidovirus-like complexity in a putative RNA virus order "Quisvirales" expands the known diversity of helicase superfamilies

Alexander E. Gorbalenya, Dmitry V. Samborskiy, Benjamin W. Neuman, Chris Lauber

The paper identifies a new order of RNA viruses, Quisvirales, with a novel helicase superfamily replacing the nidovirus SF1 helicase, suggesting convergent evolution of large replicases.

Virus Evolution · Jan 1, 2026Peer-reviewedMicrobiology

RNA genome expansion up to 64 kb in nidoviruses is host constrained and associated with new modes of replicase expression

Benjamin W. Neuman, Alexandria Smart, Orian Gilmer, Redmond P. Smyth, Josef Vaas, Nicolai Böker, Dmitry V. Samborskiy, Ralf F. W. Bartenschlager, Stefan Seitz, Alexander E. Gorbalenya, N. E. Caliskan, Chris Lauber

The paper expands the known range of nidovirus genomes up to 64 kb and identifies host constraints and new replicase expression modes in giant invertebrate nidoviruses.

Proceedings of the National Academy of Sciences · Feb 10, 2025Peer-reviewedMicrobiology