Molecular BiologyPLoS ONEPeer-reviewed
The intermediate proteasome is constitutively expressed in pancreatic beta cells and upregulated by stimulatory, non-toxic concentrations of interleukin 1 b
Muhammad Saad Khilji, Danielle Verstappen, Tina Dahlby…·Michał Marzec
The paper shows that inducible proteasomal subunits are constitutively expressed in pancreatic beta cells and upregulated by IL-1β, enhancing proteasome activity and potentially influencing autoantigen presentation.