The intermediate proteasome is constitutively expressed in pancreatic beta cells and upregulated by stimulatory, non-toxic concentrations of interleukin 1 b
Muhammad Saad Khilji, Danielle Verstappen, Tina Dahlby, Michala Cecilie Burstein Prause, Celina Pihl, Sophie Emilie Bresson, Tenna Holgersen Bryde, Kristian Klindt, Dušan Živković, Marie‐Pierre Bousquet, Björn Tyrberg, Nils Billestrup, Thomas R Mandrup-Poulsen, Michał Marzec
The paper shows that inducible proteasomal subunits are constitutively expressed in pancreatic beta cells and upregulated by IL-1β, enhancing proteasome activity and potentially influencing autoantigen presentation.
PLoS ONE · Feb 13, 2020Peer-reviewedMolecular Biology