Tina Dahlby

This study shows that GPR180 deficiency impairs mitochondrial function and first-phase insulin secretion in pancreatic β-cells without affecting insulin sensitivity.

This study shows that impaired proinsulin handling in β-cells increases MHC-I bound peptides and activates inflammasomes, potentially contributing to autoimmune diabetes.

The paper shows that inducible proteasomal subunits are constitutively expressed in pancreatic beta cells and upregulated by IL-1β, enhancing proteasome activity and potentially influencing autoantigen presentation.