Björn Tyrberg

The paper identifies IAPP as a marker for mature stem cell-derived β cells that maintain stable insulin production in vitro and in vivo, and finds that aconitine enhances IAPP expression.

The paper shows that inducible proteasomal subunits are constitutively expressed in pancreatic beta cells and upregulated by IL-1β, enhancing proteasome activity and potentially influencing autoantigen presentation.