Functional avidity of anti-B7H3 CAR-T constructs predicts antigen density thresholds for triggering effector function
Marta Barisa, Henrike P. Muller, Elisa Zappa, Rivani Shah, Juliane L. Buhl, Benjamin Draper, Courtney Himsworth, Chantelle Bowers, Sophie Munnings-Tomes, Marilena Nicolaidou, Sonia Morlando, Kathleen Birley, Clara Leboreiro-Babe, Alice Vitali, Laura Privitera, , John Anderson
The paper evaluates how the functional avidity of anti-B7H3 CAR-T constructs relates to their ability to trigger effector function against tumors with varying antigen density.
Nature Communications · Aug 5, 2025Peer-reviewedBioengineering