Blocking MIF secretion enhances CAR T-cell efficacy against neuroblastoma
Josephine G. M. Strijker, Guillem Pascual‐Pasto, Grant P. Grothusen, Yannine J. Kalmeijer, Elisavet Kalaitsidou, Chunlong Zhao, Brendan C. McIntyre, Stephanie Matlaga, Lindy L. Visser, Marta Barisa, Courtney Himsworth, Rivani Shah, Henrike P. Muller, Linda G. Schild, Peter G. Hains, , Judith Wienke
This study identifies MIF as a key immunosuppressive factor in neuroblastoma that inhibits CAR T-cell efficacy, showing that blocking MIF enhances T-cell activation and therapeutic potential.
European Journal of Cancer · Jan 27, 2025Peer-reviewedCancer Biology