Author

Lucia M. Morstadt

Fred and Pamela Buffett Cancer CenterORCID 0000-0002-4972-6086Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:chromatin & epigenetic regulation· 2 Assay:DNA methylation· 2 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Andrey G. BaranovskiyiD· 3 shared Nigar D. BabayevaiD· 3 shared Tahir H. TahiroviD· 3 shared Ci Ji LimiD· 1 shared Eduardo E. Romero· 1 shared Qixiang HeiD· 1 shared Yoshiaki SuwaiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

7 top collaborators · 18 mutual co-author links

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3 shared papersBiochemistry

Andrey G. BaranovskiyORCID

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3 papers

Recent·Most cited

Structural Basis of Herpesvirus Helicase-Primase Inhibition by Pritelivir and Amenamevir

Andrey G. Baranovskiy, Qixiang He, Yoshiaki Suwa, Lucia M. Morstadt, Nigar D. Babayeva, Ci Ji Lim, T.H. Tahirov

This study determines the cryo-EM structures of HSV-1 helicase-primase complex with and without inhibitors, revealing how pritelivir and amenamevir block helicase activity.

Science Advances · Nov 7, 2025Peer-reviewedBiochemistry

Nsp1 stalls DNA Polymerase alpha at DNA hairpins

Andrey G. Baranovskiy, Lucia M. Morstadt, Nigar D. Babayeva, T. H. Tahirov

This study shows Nsp1 inhibits DNA synthesis at hairpin-forming inverted repeats by competing with RPA's wHTH domain on Pol, with a lower IC50 than wHTH.

Scientific Reports · May 21, 2025Peer-reviewedBiochemistry

Human primosome requires replication protein A when copying DNA with inverted repeats

Andrey G. Baranovskiy, Lucia M. Morstadt, Eduardo E. Romero, Nigar D. Babayeva, Tahir H. Tahirov

This study shows RPA is critical for human primosome DNA synthesis across inverted repeats, with a specific winged helix-turn-helix domain enhancing RPA-Pol cooperation and structural integration.

bioRxiv · Mar 11, 2024 · PreprintBiochemistry