Andrey G. Baranovskiy

Structural Basis of Herpesvirus Helicase-Primase Inhibition by Pritelivir and Amenamevir

This study determines the cryo-EM structures of HSV-1 helicase-primase complex with and without inhibitors, revealing how pritelivir and amenamevir block helicase activity.

Nsp1 stalls DNA Polymerase alpha at DNA hairpins

This study shows Nsp1 inhibits DNA synthesis at hairpin-forming inverted repeats by competing with RPA's wHTH domain on Pol, with a lower IC50 than wHTH.

Human primosome requires replication protein A when copying DNA with inverted repeats

This study shows RPA is critical for human primosome DNA synthesis across inverted repeats, with a specific winged helix-turn-helix domain enhancing RPA-Pol cooperation and structural integration.

Replication protein A binds RNA and promotes R-loop formation

This study shows RPA binds RNA and promotes R-loop formation, suggesting a role in RNA metabolism and genome maintenance.