Chieko Mineo

This study identifies APOE4 as a risk factor for thrombosis by promoting vWF secretion through ApoER2 and PP2A activation in endothelial cells, leading to increased thrombosis in mice and human veins.

This study identifies two factors, hypercholesterolemia and disturbed blood flow, that upregulate endothelial SR-BI to drive LDL transport and atherosclerosis.

This study identifies scavenger receptor BI as a critical heme scavenger that protects against hemolysis, showing its therapeutic potential in hemolytic disorders.

This study shows that liver-specific SR-BI deficiency in mice increases susceptibility to CLP-induced sepsis, highlighting RCT's role in sepsis resistance.