Author

Kenian Chen

The University of Texas Southwestern Medical CenterORCID 0000-0002-4083-841XUnclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Kenian Chen1 paper

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Chieko MineoiD· 2 shared Lin Xu· 2 shared Philip W. ShauliD· 2 shared Anastasia SacharidouiD· 1 shared Andrew S. LemoffiD· 1 shared Bo Li· 1 shared DENNIS BURNS· 1 shared Jiayu ZhuiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersPathology

Chieko MineoORCID

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3 papers

Recent·Most cited

ApoE4 Promotes Thrombosis via Endothelial Cell ApoER2 and PP2A Activation

Yike Sun, Anastasia Sacharidou, Kenian Chen, Andrew S. Lemoff, Shiva Keshava, Vijaya Mohan Rao, Lin Xu, Chieko Mineo, Philip W. Shaul

This study identifies APOE4 as a risk factor for thrombosis by promoting vWF secretion through ApoER2 and PP2A activation in endothelial cells, leading to increased thrombosis in mice and human veins.

bioRxiv · Aug 21, 2026 · PreprintPathology

Coronary Artery Disease Transcriptomics Reveals Two Drivers of the Endothelial Cell SR-BI Expression and LDL Transport that Underlie Atherosclerosis

Linzhang Huang, Yibin Huang, Jiayu Zhu, Jun Peng, Kenian Chen, Ken L. Chambliss, Qinbo Zhou, Ryan J. Vela, DENNIS BURNS, Bo Li, Matthias Peltz, Yun Hua Fang, Lin Xu, Chieko Mineo, Philip W. Shaul

This study identifies two factors, hypercholesterolemia and disturbed blood flow, that upregulate endothelial SR-BI to drive LDL transport and atherosclerosis.

bioRxiv · Aug 6, 2026 · PreprintCell Biology

Actinomycin D and bortezomib disrupt protein homeostasis in Wilms tumor

Patricia D.B. Tiburcio, Kenian Chen, Lin Xu, Kenneth Sung-Man Chen

This study shows that actinomycin D and bortezomib disrupt protein homeostasis in Wilms tumor, sensitizing anaplastic cells to treatment and improving survival in xenograft models.

Cell Reports Medicine · May 1, 2025Peer-reviewedCancer Biology