Author

Neil A. Holmes

John Innes CentreORCID 0000-0002-4979-9680Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Neil A. Holmes1 paper

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 4 Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Assay:ChIP-seq· 2 Research Focus:gene regulatory network inference· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

Ainsley D. M. BeatoniD· 3 shared Barrie M. WilkinsoniD· 3 shared Gerhard SaalbachiD· 3 shared Matthew I. HutchingsiD· 3 shared Govind ChandraiD· 2 shared Lucas BalisiD· 2 shared Rhea StringeriD· 2 shared Agnieszka StrzałkaiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersMicrobiology

Ainsley D. M. BeatonORCID

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4 papers

Recent·Most cited

Defining the OrrA regulon and its role in development and antibiotic production in Streptomyces venezuelae NRRL B-65442

Kelly-Rose Tulley, Lucas Balis, Neil A. Holmes, Ainsley D. M. Beaton, Courtney Andrews, Gerhard Saalbach, Rhea Stringer, Govind Chandra, Barrie M. Wilkinson, Matthew I. Hutchings

This study defines the OrrA regulon in Streptomyces venezuelae, showing it regulates sporulation and antibiotic production via WblA.

Microbiology · May 28, 2026Peer-reviewedMicrobiology

MtrAB activates ectoine production and triggers sporulation in response to osmotic stress in Streptomyces venezuelae

Ainsley D. M. Beaton, Rebecca Devine, Neil A. Holmes, Nicolle F. Som, Lucas Balis, Katie Noble, Rhea Stringer, Martin Rejzek, Gerhard Saalbach, Barrie M. Wilkinson, Matthew I. Hutchings

This paper shows that MtrAB in Streptomyces venezuelae senses osmotic stress via sucrose, activates ectoine production, and triggers sporulation through direct regulation of bldM and whiI.

Microbiology · May 20, 2026Peer-reviewedMicrobiology

The conserved two-component systems CutRS and CssRS control the protein secretion stress response in Streptomyces species

Thomas C. McLean, Ainsley D. M. Beaton, Neil A. Holmes, Carlo Martins, Gerhard Saalbach, Govind Chandra, Sibyl F. D. Batey, Jana China, Barrie M. Wilkinson, Matthew I. Hutchings

This paper identifies CutRS as a two-component system in Streptomyces that senses secretion stress via cysteine residues and regulates antibiotic production in response to glucose.

bioRxiv · Mar 20, 2025 · PreprintMicrobiology

The role of two major nucleoid associated proteins in Streptomyces, HupA and HupS, in stress survival and gene expression regulation

Agnieszka Strzałka, Jakub Mikołajczyk, Klaudia Kowalska, Michał Skurczyński, Neil A. Holmes, Dagmara Jakimowicz

This study investigates the roles of HupA and HupS in Streptomyces coelicolor growth, stress survival, and gene expression regulation, finding they act synergistically and as global transcription regulators.

Microbial Cell Factories · Oct 14, 2024Peer-reviewedMicrobiology