Thomas C. McLean

This paper shows TrbA interacts with KorB to lock it as a transcriptional repressor on multi-drug resistance plasmids, using a conserved aromatic interface.

The paper investigates dual ParABS partition systems in Streptomyces plasmid SCP1, showing that while both systems are functional, only parABS1 is essential for plasmid maintenance.

The paper shows that the ParB-CTPase fold can be repurposed as an ATPase toxin in bacterial contact-dependent growth inhibition systems, with toxic effects in both plant and animal cells.

This study identifies EGF7 in PfRipr as a critical domain for inhibiting Plasmodium falciparum erythrocyte invasion and provides a basis for vaccine design.

This paper identifies CutRS as a two-component system in Streptomyces that senses secretion stress via cysteine residues and regulates antibiotic production in response to glucose.

The paper shows that KorB, a DNA-sliding clamp, switches to a repressor role with KorA to mediate long-range gene silencing on plasmid RK2.

This study shows that inactivating the upf31 gene in a plasmid improves its maintenance in E. coli by altering gene regulation, demonstrating how plasmid evolution can affect host range.