Neurosciencenpj Parkinson s DiseasePeer-reviewed
Neither alpha-synuclein-preformed fibrils derived from patients with GBA1 mutations nor the host murine genotype significantly influence seeding efficacy in the mouse olfactory bulb.
Sara Walton, Alexis Fenyi, Tyler Tittle…·Jeffrey H. Kordower
The study tests whether GBA1 mutations or mouse genotype affect alpha-synuclein seeding in mice, finding no significant influence on seeding efficacy or pathology spread.
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