Comprehensive analysis of tumour initiation, spatial and temporal progression under multiple lines of treatment
Ignaty Leshchiner, Dimitri G. Livitz, Justin F. Gainor, Daniel Rosebrock, Oliver Spiro, Aina Zurita Martinez, Edmund A. Mroz, Jessica J. Lin, Chip Stewart, Jaegil Kim, Liudmila Elagina, Ivana Božić, Mari A. Mino-Kenudson, Marguerite M. Rooney, Sai‐Hong Ignatius Ou, , Gad A. Getz
PhylogicNDT statistically reconstructs cancer driver timing, subclonal phylogenies, and population dynamics from single- or multi-timepoint sequencing, revealing subtype-specific trajectories and therapy resistance evolution across 498 lung adenocarcinomas.
bioRxiv · Feb 16, 2019 · PreprintBioinformatics