Author

Oliver Spiro

Broad Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Research Focus:variant calling· 2 Assay:whole-exome sequencing· 2 Assay:whole-genome sequencing· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Chip StewartiD· 2 shared Daniel RosebrockiD· 2 shared Dimitri G. LivitziD· 2 shared Gad A. GetziD· 2 shared Ignaty LeshchineriD· 2 shared Jaegil KimiD· 2 shared Liudmila Elagina· 2 shared Aina Zurita MartineziD· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersGenomics

Chip StewartORCID

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Author profile →

3 papers

Recent·Most cited

Comprehensive Longitudinal ctDNA Monitoring in Metastatic Cancer Patients Treated with an Individualized Neoantigen-directed Vaccine

Desiree Schenk, Matthew J. Davis, Rita Zhou, Alexis Mantilla, Madeline Galbraith, Oliver Spiro, Olivia Petrillo, Ítalo Faria do Valle, Andrew R. Ferguson, Karin U. Jooss, Ankur Dhanik

This study monitors ctDNA in metastatic cancer patients receiving an individualized vaccine, showing the assay's sensitivity and insights into treatment response.

bioRxiv · Dec 4, 2024 · PreprintGenomics

Combined tumor and immune signals from genomes or transcriptomes predict outcomes of checkpoint inhibition in melanoma

Samuel S. Freeman, Moshe Sade-Feldman, Jaegil Kim, Chip Stewart, Anna L. K. Gonye, Arvind Ravi, Monica B. Arniella, Irena Gushterova, Thomas James LaSalle, Emily M. Blaum, Keren Yizhak, Dennie Tompers Frederick, Tatyana Y. Sharova, Ignaty Leshchiner, Liudmila Elagina, , Nir Hacohen

The paper develops DNA- and RNA-based models combining immune and tumor features to predict outcomes of checkpoint inhibition in melanoma.

Cell Reports Medicine · Feb 1, 2022Peer-reviewedGenomics

Comprehensive analysis of tumour initiation, spatial and temporal progression under multiple lines of treatment

Ignaty Leshchiner, Dimitri G. Livitz, Justin F. Gainor, Daniel Rosebrock, Oliver Spiro, Aina Zurita Martinez, Edmund A. Mroz, Jessica J. Lin, Chip Stewart, Jaegil Kim, Liudmila Elagina, Ivana Božić, Mari A. Mino-Kenudson, Marguerite M. Rooney, Sai‐Hong Ignatius Ou, , Gad A. Getz

PhylogicNDT statistically reconstructs cancer driver timing, subclonal phylogenies, and population dynamics from single- or multi-timepoint sequencing, revealing subtype-specific trajectories and therapy resistance evolution across 498 lung adenocarcinomas.

bioRxiv · Feb 16, 2019 · PreprintBioinformatics