Author

Jeffrey Vedanayagam

Memorial Sloan Kettering Cancer CenterORCID 0000-0002-5013-7860Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Evolutionary Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:Drosophila· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Organism:C. elegans· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:gene regulatory network inference· 1 Research Focus:genome assembly· 1

Frequent Co-Authors

Amanda M. LarracuenteiD· 1 shared Ching-Ho ChangiD· 1 shared Colin D. MeiklejohniD· 1 shared Danielle E. KhostiD· 1 shared Eric C. LaiiD· 1 shared J. J. EmersoniD· 1 shared Jeffrey R. AdrioniD· 1 shared Jodh Singh PannuiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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1 shared paperGenomics

Amanda M. LarracuenteORCID

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3 papers

Recent·Most cited

Calibrated structural homology transfer yields putative molecular functions for domains of unknown function in four model proteomes

Jodh Singh Pannu, Kendall Green, Jeffrey Vedanayagam

The paper evaluates functional annotation reliability from remote homology searches using retrospective DUFs and finds Foldseek performs better than MMseq2 but not significantly better than ESM-2 embeddings.

bioRxiv · Sep 16, 2026 · PreprintBioinformatics

Structure-informed evolutionary analysis of the meiotic recombination machinery

Meret Arter, Jeffrey Vedanayagam, Min Lu, Momar Diop, Kaixian Liu, Eric C. Lai, Scott Keeney

The paper analyzes evolutionary divergence in meiotic recombination proteins across four taxa, identifying regions under positive selection and functional constraints using structural and functional data.

bioRxiv · Nov 7, 2025 · PreprintEvolutionary Biology

Evolution of genome structure in the Drosophila simulans species complex

Mahul Chakraborty, Ching-Ho Chang, Danielle E. Khost, Jeffrey Vedanayagam, Jeffrey R. Adrion, Yi Liao, Kristi L. Montooth, Colin D. Meiklejohn, Amanda M. Larracuente, J. J. Emerson

The paper generates high-quality genomes for Drosophila simulans species complex to study repetitive DNA evolution and structural divergence between species.

Genome Research · Mar 1, 2021Peer-reviewedGenomics