Targeting CREB remodels the immune microenvironment to enhance immunotherapy responses in pancreatic cancer
Siddharth Mehra, Supriya Srinivasan, Sudhakar Jinka, Varunkumar Krishnamoorthy, Vineet Kumar Gupta, Vanessa T. Garrido, Anna Bianchi, Andrew Mark Adams, Manan S. Patel, Haleh Amirian, Luis Alberto Nivelo, Karthik Rajkumar, Rimpi Khurana, Edmond W. Box, Yuguang J. Ban, , Nagaraj S. Nagathihalli
This study shows that targeting CREB reduces immunosuppression in pancreatic cancer by altering macrophage polarization and enhancing immunotherapy effectiveness.
bioRxiv · Dec 8, 2025 · PreprintCancer Biology