Author

Siddharth Mehra

University of MiamiORCID 0000-0003-1639-8087Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Haleh AmirianiD· 3 shared Jashodeep DattaiD· 3 shared Nagaraj S. NagathihalliiD· 3 shared Nipun B. MerchantiD· 3 shared Anna BianchiiD· 2 shared Austin R. DoschiD· 2 shared Edmond W. BoxiD· 2 shared Iago De Castro SilvaiD· 2 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

Haleh AmirianORCID

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintDec 8, 2025

Targeting CREB remodels the immune microenvironment to enhance immunotherapy responses in pancreatic cancer

Siddharth Mehra, Supriya Srinivasan, Sudhakar Jinka…·Nagaraj S. Nagathihalli

This study shows that targeting CREB reduces immunosuppression in pancreatic cancer by altering macrophage polarization and enhancing immunotherapy effectiveness.

DOI 10.64898/2025.12.04.691935

mousebulk RNA-seq

𝕏 PostBluesky

Cancer BiologyCancer Immunology ImmunotherapyPeer-reviewedJun 23, 2025

Cell-specific nanoengineering strategy disrupts tolerogenic signaling from myeloid-derived suppressor cells to invigorate antitumor immunity in pancreatic cancer

Nilesh Deshpande, Anna Bianchi, Haleh Amirian…·Jashodeep Datta

The paper develops CXCR2-homing nanoparticles to specifically target PMN-MDSCs in PDAC, reducing arginase activity and enhancing T-cell activity without causing neutropenia.

10 citations

mouseexperimental assay

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Cancer BiologyCellular and Molecular Gastroenterology and HepatologyPeer-reviewedJan 1, 2025

CREB drives acinar cells to ductal reprogramming and promotes pancreatic cancer progression in preclinical models of alcoholic pancreatitis

Supriya Srinivasan, Siddharth Mehra, Sudhakar Jinka…·Nagaraj S. Nagathihalli

This study shows CREB promotes acinar-to-ductal reprogramming and pancreatic cancer progression in alcoholic pancreatitis models by enhancing fibrosis and tumor growth.

9 citations

mousebulk RNA-seq

𝕏 PostBluesky