ImmunologybioRxivPreprint
A feed-forward loop between niche adenosine and Gzmk⁺ CD8 T cells propagates systemic inflammaging
Lin Guo, Rui Zheng, Qianqian Zhan…·Wenqiang Cao
This study identifies an adenosine-Gzmk axis that drives T cell aging and systemic inflammaging, showing that targeting it can reverse aging phenotypes and extend lifespan in mice.