Author

Siqi Zhou

Center for Disease Biology and Integrative Medicine, The University of TokyoORCID 0000-0002-5024-7269Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:drug response / drug discovery· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Haruo KasaiiD· 2 shared Hitoshi OkazakiiD· 2 shared Masanari OhtsukaiD· 2 shared Takeshi SawadaiD· 2 shared Tomoki Arima· 2 shared Kenichi OhkiiD· 1 shared Kota Homma· 1 shared M MatsuzakiiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersNeuroscience

Haruo KasaiORCID

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2 papers

Recent·Most cited

uniSynK: a ratio-optimized bicistronic chemically induced dimerization tool for robust induction of dendritic spine enlargement

Kota Homma, Masanari Ohtsuka, Siqi Zhou, Hitoshi Okazaki, Tomoki Arima, Haruo Kasai, Takeshi Sawada

The paper develops uniSynK, a single-vector chemogenetic tool that optimizes the expression ratio of two components to robustly induce dendritic spine enlargement with fewer off-target effects.

eNeuro · Sep 1, 2026Peer-reviewedNeuroscience

Rapid associative spine enlargement is required for cognitive function and stable wakefulness

Siqi Zhou, Takeshi Sawada, Hitoshi Okazaki, Tomoki Arima, Shunki Takaramoto, Saddam Khan Panezai, Masanari Ohtsuka, Shin-Ichiro Terada, Masashi Kondo, Takaaki Hashimoto, Kenichi Ohki, M Matsuzaki, Sho Yagishita, Haruo Kasai

This study shows that rapid associative spine enlargement is necessary for maintaining cognitive function and stable wakefulness in mice.

bioRxiv · Nov 6, 2025 · PreprintNeuroscience