Transcriptomic signatures of host immune responses in aphthous ulcers, the earliest lesions of Crohn's disease, suggest that a bacterial invasive challenge, rather than global dysbiosis, is the initiating factor.
Phillip J Whiley, Ojas V. A. Dixit, Mukta Das Gupta, Hardip R. Patel, Guoyan Zhao, Susan Jane Connor, KIM M. SUMMERS, David Arthur Hume, Paul Pavli, Claire Louise O'Brien
The paper identifies transcriptomic signatures in aphthous ulcers of Crohn's disease, suggesting bacterial invasion initiates inflammation rather than dysbiosis.
Immunology and Cell Biology · May 1, 2025Peer-reviewedImmunology