Guoyan Zhao

This paper creates a multi-omic atlas of human autonomic and sensory ganglia, identifying cell-type-specific features and disease associations in peripheral neuropathies.

The paper identifies microglial states and activation genes in aging and parabiosis, revealing region-specific responses and vulnerabilities in the brain.

This paper constructs a human dorsal root ganglion reference atlas, identifying 22 neuronal subtypes and 10 non-neuronal cell types, and reveals functional differences between human and mouse DRG neurons.

This study creates a single-nucleus multi-omic atlas of human dorsal root ganglia, identifying novel regulatory mechanisms and therapeutic targets for pain.

The paper identifies transcriptomic signatures in aphthous ulcers of Crohn's disease, suggesting bacterial invasion initiates inflammation rather than dysbiosis.

This study compares the DRG microenvironment's response to peripheral and central axon injuries using single-cell profiling, identifying PPAR pathway activation in satellite glial cells as critical for peripheral regeneration.

The paper identifies chromatin accessible sites and transcription factors in RGCs that correlate with axon growth capacity and shows CREB overexpression promotes axon regeneration.

This study shows that spinal cord injury (SCI) in dorsal column sensory neurons leads to downregulation of lipid metabolism genes, unlike sciatic nerve injury, which may hinder axon regeneration.