Author

Claire Louise O'Brien

University of CanberraORCID 0000-0003-1599-9913Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

David Arthur HumeiD· 2 shared KIM M. SUMMERSiD· 2 shared Ojas V. A. DixitiD· 2 shared Paul PavliiD· 2 shared Dylan Carter‐CusackiD· 1 shared Guoyan ZhaoiD· 1 shared Hardip R. PateliD· 1 shared Mukta Das GuptaiD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersImmunology

David Arthur HumeORCID

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2 papers

Recent·Most cited

ImmunologyImmunology and Cell BiologyPeer-reviewedMay 1, 2025

Transcriptomic signatures of host immune responses in aphthous ulcers, the earliest lesions of Crohn's disease, suggest that a bacterial invasive challenge, rather than global dysbiosis, is the initiating factor.

Phillip J Whiley, Ojas V. A. Dixit, Mukta Das Gupta…·Claire Louise O'Brien

The paper identifies transcriptomic signatures in aphthous ulcers of Crohn's disease, suggesting bacterial invasion initiates inflammation rather than dysbiosis.

1 citation

humanbulk RNA-seq

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GeneticsbioRxivPreprintDec 14, 2022

The association between transcriptional regulation of macrophage differentiation and activation and genetic susceptibility to inflammatory bowel disease

Claire Louise O'Brien, KIM M. SUMMERS, Natalia M Martin…·Paul Pavli

This study examines transcriptomic variation in macrophages from IBD families and finds extreme individual variation in gene expression linked to HLA genotype and genetic susceptibility to IBD.

DOI 10.1101/2022.12.14.520373

humanbulk RNA-seq

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