Sarah Jane Appleby

This paper demonstrates that morula complementation with donor cells restores fetal kidney development in SALL1-null sheep, establishing sheep as a viable model for in vivo organ generation.

This paper generates cloned sheep lacking two xenoantigens, Gal and Neu5Gc, by knocking out their respective genes, creating a model that better mimics human immune status for preclinical testing.

The paper generates DAZL-null sheep that lack germ cells but have normal somatic cells, demonstrating the feasibility of using absolute donor germline transmitters in livestock breeding.