Zachariah L. McLean

This study investigates the role of WWOX in DNA damage and somatic instability in Huntington's disease, finding that WWOX promotes DNA damage but not CAG repeat instability.

TRACE is an open-source software that quantifies somatic instability of tandem repeats using capillary electrophoresis data, providing accessible tools for analyzing repeat expansion.

This paper generates cloned sheep lacking two xenoantigens, Gal and Neu5Gc, by knocking out their respective genes, creating a model that better mimics human immune status for preclinical testing.

The paper identifies genetic modifiers of somatic CAG expansion and clinical phenotypes in Huntington's disease, revealing shared and tissue-specific effects on disease timing and pathogenic processes.

This study shows splice modulators like branaplam reduce HTT CAG repeat expansion by affecting PMS1 expression, suggesting PMS1 as a new therapeutic target for Huntington's disease.

The paper generates DAZL-null sheep that lack germ cells but have normal somatic cells, demonstrating the feasibility of using absolute donor germline transmitters in livestock breeding.