Insulin fails to mitigate amyloid pathology but modulates intestinal morphology in the 5xFAD model revealed by synchrotron-based XPCT
Esra Beyarslan Ayan, Francesca Palermo, Giorgia Cavioli, Sevginur Bostan, Büşra Züleyha Doğan, Kader Kılıç, Arife Ahsen Kaplan, Inna Bukreeva, Lorenzo Massimi, Elena Longo, Gulsena Baydas, Ahmet Katı, Emrah Eroğlu, Gürkan Öztürk, Muhammed İkbal Alp, Alessia Cedola
This study shows intranasal insulin does not reduce brain amyloid plaques in 5xFAD mice but changes intestinal morphology and fecal metaproteomics.
bioRxiv · Oct 16, 2026 · PreprintBiophysics