Óscar González-Velasco

The paper investigates functional differences between EML4-ALK variants V1 and V3 in lung cancer using mouse models and human data, showing variant-specific effects on tumorigenesis.

This study identifies somatic mutations in ALS genes in the motor cortex of sporadic ALS patients, particularly in excitatory neurons, suggesting a role in disease initiation.

The paper introduces CFS, a method to compare cell groups across datasets without integration, identifying conserved astrocyte subpopulations in mouse motor cortex and spinal cord.

LotOfCells is an R package that visualizes and statistically analyzes single-cell metadata to assess changes in cell type proportions across conditions.

The paper introduces a method to measure similarity between cell clusters across different datasets without batch correction, using log fold-changes and provides a tool for this purpose.