Rocı́o Sotillo

Loss of the Y chromosome drives epigenetic and transcriptomic plasticity in lung adenocarcinoma

This study shows that loss of the Y chromosome in lung adenocarcinoma causes epigenetic and transcriptomic changes that increase lineage plasticity and poor clinical outcomes.

EML4-ALK variant-specific genetic interactions shape lung tumorigenesis

The paper investigates functional differences between EML4-ALK variants V1 and V3 in lung cancer using mouse models and human data, showing variant-specific effects on tumorigenesis.

Efficient and multiplexed somatic genome editing with Cas12a mice

This study develops transgenic Cas12a mice to enable efficient, multiplexed somatic genome editing for studying complex genetic interactions in vivo.

Osmotic Stress Influences Microtubule Drug Response Via WNK1 Kinase Signaling

The paper identifies WNK1 kinase as a modulator of microtubule drug response under osmotic stress, showing altered drug sensitivity due to changes in microtubule stability.

A Lung Cancer Mouse Model Database

The paper establishes a database of lung cancer mouse models to improve data comparison and translational relevance by aligning mouse mutations with human lung cancer mutations.

Acute expression of human APOBEC3B in mice causes lethality associated with RNA editing

This study shows that overexpressing human APOBEC3B in mice causes lethality through RNA editing and organ dysfunction.