Zhenguo Lin

The Patterns of Alternative TSS Usage Explain the Highly Heterogeneous Landscape of 5'UTR Lengths in Eukaryotes

The paper investigates how alternative TSS usage correlates with gene expression and translation efficiency across eukaryotes, revealing its role in regulating protein production.

A new chromosome-level genome assembly for western painted turtle Chrysemys picta belli, a model for extreme physiological adaptations

The paper presents a new chromosome-level genome assembly for the western painted turtle, improving upon a previous fragmented assembly and revealing novel genes and transcript isoforms.

Yeast poly(A)-binding protein (Pab1) controls translation initiation in vivo primarily by blocking mRNA decapping and decay

This study shows that Pab1 in yeast primarily controls translation by blocking mRNA decapping and decay, with reduced mRNA abundance driving translational changes.

Modulation of ribosomal subunit associations by eIF6 is critical for mitotic exit and cancer progression.

This study shows that eIF6 modulates ribosomal subunit associations, affecting mitotic exit and cancer progression by altering translation efficiency of mitotic factors.

Chromosome-level Subgenome-aware de novo Assembly of Saccharomyces bayanus Provides Insight into Genome Divergence after Hybridization

This study assembles the chromosome-level genome of Saccharomyces bayanus and compares it to its parental species to understand genome divergence after hybridization.

Decapping factor Dcp2 controls mRNA abundance and translation to adjust metabolism and filamentation to nutrient availability

This study shows that Dcp2 regulates mRNA abundance and translation to adjust metabolism and filamentation in response to nutrient availability in yeast.

Transcriptome analysis provides genome annotation and expression profiles in the central nervous system of Lymnaea stagnalis at different ages

The paper provides age-specific transcriptome analysis and gene annotations for the central nervous system of Lymnaea stagnalis, revealing differentially expressed genes and pathways across developmental stages.

The origin and evolution of a distinct mechanism of transcription initiation in yeasts

The paper identifies the origin of the scanning model of transcription initiation in yeasts and shows that an adenine-rich region upstream of TSSs facilitates TSS selection.

Gap junction coding innexin in Lymnaea stagnalis: sequence analysis and characterization in tissues and the central nervous system

The paper identifies and characterizes eight innexin genes in the CNS of Lymnaea stagnalis, revealing their evolutionary origin and tissue-specific expression patterns.

Quantifying the RNA cap epitranscriptome reveals novel caps in cellular and viral RNA

The paper introduces CapQuant, a mass spectrometry-based method to analyze RNA caps, revealing new cap structures and variations in humans and mice.

Pervasive and Dynamic Transcription Initiation in Saccharomyces cerevisiae

This study maps transcription start sites in yeast under nine conditions, revealing pervasive and dynamic transcription initiation with core promoters that shift in response to environmental changes.

YeasTSS: An Integrative Web Database of Yeast Transcription Start Sites

The paper introduces YeasTSS, a database providing quantitative TSS maps and core promoters for twelve yeast species, along with integrated functional genomic data for transcription initiation studies.