Gonzalo López

The paper identifies genomic deletions as the rate-limiting mutational processes in breast and ovarian cancer initiation, requiring 1-3 deletions for tumor development.

This study identifies 13.9% of neuroblastoma patients with pathogenic germline variants in cancer predisposition genes, associated with worse survival and enriched in DNA repair genes like BARD1.

This study identifies somatic structural variations in neuroblastoma, showing their enrichment in neurodevelopmental genes and the tumor suppressor role of SHANK2.

corto is a lightweight R package for gene network inference and master regulator analysis, benchmarked on human tumor and normal tissue datasets.

This paper genomically characterizes 261 pediatric cancer patient-derived xenograft models to guide rational clinical trial design and drug development.