Author

Mahad Bihie

McMaster University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Assay:whole-genome sequencing· 3 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Kuan‐lin HuangiD· 3 shared Julián Grandvallet ContrerasiD· 2 shared Yves GreattiiD· 2 shared Andrea CastroiD· 1 shared Daniel Jeremy FulopiD· 1 shared Gonzalo LópeziD· 1 shared Guanlan DongiD· 1 shared Hannah K. CarteriD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersCancer Biology

Kuan‐lin HuangORCID

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3 papers

Recent·Most cited

Tissue-Specific Prevalence and Clonal Architecture of BRCA1/2 LOH-Inducing Chromosomal Aneuploidy

Xinfeng Wang, Saumya Dushyant Sisoudiya, Mahad Bihie, Yves Greatti, Julián Grandvallet Contreras, Tomi Wei Jun, Smruthy Sivakumar, Kuan‐lin Huang

The paper investigates tissue-specific chromosomal deletions in BRCA1/2-related cancers using bulk and single-cell data, finding early deletions of 17q and 13q in breast and ovarian cancers.

bioRxiv · Apr 21, 2026 · PreprintCancer Biology

Deletions Rate-Limit Breast and Ovarian Cancer Initiation

Kathleen E. Houlahan, Mahad Bihie, Yves Greatti, Julián Grandvallet Contreras, Daniel Jeremy Fulop, Gonzalo López, Marc J. Williams, Hsin-Hsiung Huang, Peter Van Loo, Paul C. Boutros, Kuan-lin Huang

The paper identifies genomic deletions as the rate-limiting mutational processes in breast and ovarian cancer initiation, requiring 1-3 deletions for tumor development.

EBioMedicine · Feb 21, 2026Peer-reviewedCancer Biology

Widespread Epistasis between Cancer Driver Mutations and Allele-Specific Copy Number Variations

Serge Merzliakov, Guanlan Dong, Andrea Castro, Mahad Bihie, Yve Nichols-Evans, Hannah K. Carter, Kuan‐lin Huang

The paper identifies epistatic interactions between cancer driver mutations and allele-specific copy number variations in tumors, showing their impact on patient survival.

bioRxiv · Dec 14, 2025 · PreprintGenomics