Intratumoral plasma cells are required for activation of CD8+ T cells and success of immune checkpoint blockade therapy in de novo MPNSTs
Joshua J. Lingo, Ryan J. Reis, Chantal Allamargot, Juan A. Raygoza Garay, Courtney A. Kaemmer, Elizabeth C. Elias, Ellen M. Voigt, Ali Jabbari, Connor R. Wilhelm, Alexander W. Boyden, Nitin J. Karandikar, Patrick John Breheny, David Kyle Meyerholz, Rebecca D. Dodd, Jon C. D. Houtman, , Dawn E. Quelle
This study shows that intratumoral plasma cells are essential for CD8+ T cell activation and response to immune checkpoint blockade therapy in MPNSTs.
bioRxiv · Feb 20, 2026 · PreprintCancer Biology