Justin Crocker

The paper shows that mutation transmission is influenced by developmental and life-history traits, altering mutation rates and identities across species.

The paper investigates interallelic cis-regulatory dominance in Drosophila, showing it promotes robustness by masking deleterious variants and enables evolutionary innovation through cell-type-specific activity.

This paper introduces a method to quantify intensity distribution in 3D and 2D microscopy data using spherical harmonics, demonstrating its application across various biological systems.

The paper presents a theoretical framework showing mutation rates are influenced by developmental parameters and intraorganismal selection, not just molecular mutation rates.

This paper shows chromatin reduces regulatory errors in gene expression by silencing off-target genes and enabling scalable gene regulation.

LarvaTagger combines a pre-trained deep neural network with a GUI for manual tagging and training new automatic taggers using updated ground truth.

This study shows that fly populations rapidly adapt to increased bicoid dosage by normalizing gene expression and improving survival through metabolic and developmental changes.

The paper shows that mutations in developmental enhancers in Drosophila mostly alter existing expression patterns, while random sequences can act as enhancers with broader expression, suggesting constraints on phenotypic novelty from existing enhancers.

This study shows that H3K4me1 hypomethylation in Drosophila leads to context-dependent changes in morphology, metabolism, and behavior, suggesting it acts as a phenotypic capacitor.

The paper observes increasing nuclear heterogeneity during Drosophila embryogenesis, mirroring the complexity of body plan development.

The paper shows that multiple enhancers form transcriptional hubs that enhance robustness by retaining transcription factors, buffering against environmental and genetic stresses.

The paper describes genetic and transgenic reagents for several Drosophila species to facilitate genetic studies.

The paper shows that regulatory sequences outside a minimal enhancer can drive gene expression in a different species, highlighting functional evolution beyond minimal enhancer regions.