Melinda Liu Perkins

This paper shows chromatin reduces regulatory errors in gene expression by silencing off-target genes and enabling scalable gene regulation.

The paper shows that mutations in developmental enhancers in Drosophila mostly alter existing expression patterns, while random sequences can act as enhancers with broader expression, suggesting constraints on phenotypic novelty from existing enhancers.

The paper investigates how temporal morphogen decay and diffusion improve precision and placement of gene expression boundaries in bistable networks, using a fruit fly model.

The paper introduces a cell-in-the-loop approach to synthetic biology pattern formation, demonstrating checkerboard patterning through optogenetic signaling emulated in silico.