Fabian Ruperti

From promiscuity to specialization: The origin of cholinergic and monoaminergic signaling is pre-bilaterian

This study shows that cholinergic and monoaminergic signaling originated before Bilateria, using a combination of metabolomics, phylogenetics, and single-cell analysis.

A mobile optical coherence microscope for studying aquatic organisms in- and outside the laboratory

This paper introduces a mobile optical coherence microscope for high-resolution, label-free imaging of aquatic organisms in both lab and field settings, enabling detailed morphological and dynamic analysis.

Interallelic cis-regulatory dominance promotes robustness and evolutionary innovation

The paper investigates interallelic cis-regulatory dominance in Drosophila, showing it promotes robustness by masking deleterious variants and enables evolutionary innovation through cell-type-specific activity.

Proteomic analysis of the Aggregation Factor from the sponge Clathria (Microciona) prolifera suggests an ancient protein domain toolkit for allorecognition in animals

The paper uses proteomics to identify AF components in sponges and finds conserved domains suggesting an ancient toolkit for cell adhesion and allorecognition.

Molecular profiling of sponge deflation reveals an ancient relaxant-inflammatory response

The paper identifies an ancient relaxant-inflammatory response in sponges during deflation, driven by actomyosin relaxation and associated with inflammation-like states.

Profiling cellular diversity in sponges informs animal cell type and nervous system evolution

The paper identifies 18 cell types in sponges, including neuroid cells with synaptic gene expression, suggesting early neuro-immune system evolution.