Molecular BiologybioRxivPreprint
GalNAc-siRNA Mediated Knockdown of Ketohexokinase Versus Systemic, Small Molecule Inhibition of its Kinase Activity Exert Divergent Effects on Hepatic Metabolism in Mice on a HFD
Se‐Hyung Park, Taghreed Fadhul, Lindsey R. Conroy…·Samir Softic
This study compares the effects of GalNAc-siRNA-mediated KHK knockdown and small molecule KHK inhibition on hepatic metabolism in mice on a high-fat diet, finding divergent impacts on lipid metabolism and glucose tolerance.
DOI 10.1101/2023.08.14.553218