GalNAc-siRNA Mediated Knockdown of Ketohexokinase Versus Systemic, Small Molecule Inhibition of its Kinase Activity Exert Divergent Effects on Hepatic Metabolism in Mice on a HFD
Se‐Hyung Park, Taghreed Fadhul, Lindsey R. Conroy, Harrison A. Clarke, Ramon C. Sun, Kristina Wallenius, Jérémie Boucher, Gavin O’Mahony, Alessandro Boianelli, Marie Persson, Genesee J. Martinez, Terry D. Hinds, Senad Divanovic, Samir Softic
This study compares the effects of GalNAc-siRNA-mediated KHK knockdown and small molecule KHK inhibition on hepatic metabolism in mice on a high-fat diet, finding divergent impacts on lipid metabolism and glucose tolerance.
bioRxiv · Aug 14, 2023 · PreprintMolecular Biology