Harrison A. Clarke

This study shows systemic hypoxia promotes lung adenocarcinoma progression by mobilizing glycogen via GAA, supporting tumor growth through metabolic remodeling.

This study identifies hyper-glycosylation as a driver of Alzheimer's disease through metabolic analysis and interventions, showing its impact on cognitive decline and mortality.

MetaVision3D converts serial 2D MALDI mass spectrometry imaging sections into a 3D spatial metabolome atlas using computer vision techniques.

This study compares the effects of GalNAc-siRNA-mediated KHK knockdown and small molecule KHK inhibition on hepatic metabolism in mice on a high-fat diet, finding divergent impacts on lipid metabolism and glucose tolerance.

The paper presents a method for simultaneous spatial analysis of metabolome, lipidome, and glycome from a single tissue section using mass spectrometry imaging and a computational framework called Sami.

This paper shows that probiotic treatment after spinal cord injury improves gut health and respiratory function by reducing inflammation and enhancing neuronal regeneration.

This study investigates how APOE4 affects microglial immunometabolism across age, amyloid pathology, and inflammation using multi-omics approaches.

This study shows that cervical spinal cord injury in rats leads to acute lung injury and metabolic dysfunction, establishing a new animal model for studying this relationship.

The paper introduces Madi, a workflow combining MALDI-MSI and machine learning to analyze FFPE tissues, revealing metabolic patterns and pathological features in human tissues.