Antidepressants interact with sex steroid receptors and their intracellular signaling components
Shokouh Arjmand, M. Rezaei, Donato Sardella, Cláudia R. Cecchi, Rachele Rossi, Christian Bjerggaard Vægter, Heidi Kaastrup Müller, Jayashree Sahana, Morten Schak Nielsen, Anne Marlene Landau, Ulf Simonsen, Steffen Sinning, Gregers Wegener, Sâmia R.L. Joca, Caroline Biojone
This study shows antidepressants interact with estrogen receptor alpha and its signaling pathways, suggesting a new mechanism for their therapeutic effects in mood disorders.
bioRxiv · Mar 19, 2026 · PreprintPharmacology & Toxicology