Caroline Biojone

Antidepressants interact with sex steroid receptors and their intracellular signaling components

This study shows antidepressants interact with estrogen receptor alpha and its signaling pathways, suggesting a new mechanism for their therapeutic effects in mood disorders.

Fingolimod acutely facilitates the activation of TRKB

This study shows that fingolimod acutely activates TRKB through BDNF-dependent mechanisms, enhancing neuronal plasticity and normalizing fear responses in BDNF-deficient mice.

Mutation in the TRKB cholesterol recognition site that blocks antidepressant binding does not influence the basal or BDNF-stimulated activation of TRKB

This study shows that a TRKB mutation blocking antidepressant binding does not affect BDNF-stimulated activation or baseline TRKB function, but impairs antidepressant responses.

Nitric oxide-induced tyrosine nitration of TrkB impairs BDNF signaling and restrains neuronal plasticity

This paper shows that nitric oxide nitrates TRKB receptors, impairing BDNF signaling and reducing neuronal plasticity through endocytosis and degradation.

Perineuronal net receptor PTPσ regulates retention of memories

This study shows that reduced PTPσ expression improves short-term memory but impairs long-term memory retention in mice, suggesting PTPσ's role in memory retention through TRKB signaling.

Cholesterol recognition motifs in the transmembrane domain of the tyrosine kinase receptor family: the case for TRKB

The paper identifies CRAC and CARC motifs in RTK transmembrane domains, showing cholesterol interaction with TRKB's CARC motif and its effect on BDNF binding.

Antidepressant drugs act by directly binding to TRKB neurotrophin receptors

This study identifies a direct binding of antidepressants to TRKB receptors, revealing a mechanism linking molecular interactions to antidepressant effects.

Chondroitinase and antidepressants promote plasticity by releasing TRKB from dephosphorylating control of PTPσ in parvalbumin neurons

This study shows that chondroitinase and antidepressants promote plasticity in the adult visual cortex by enhancing TRKB signaling in parvalbumin neurons through inhibition of PTPσ.

Activation of the TRKB receptor mediates the panicolytic-like effect of NOS inhibitor aminoguanidine

The paper shows that repeated aminoguanidine administration increases TRKB phosphorylation in the dPAG, which is necessary for its panicolytic-like effect in rats.

Dual mechanism of TRKB activation by anandamide through CB1 and TRPV1 receptors

This study shows anandamide activates TRKB through CB1 and TRPV1 receptors, influencing neuronal migration and behavior in rat cortical cells.