Anne Marlene Landau

This study validates 5-MOP as a highly selective CSF1R radioligand with nanomolar affinity, enabling accurate detection of drug occupancy and microglial activation.

This study shows antidepressants interact with estrogen receptor alpha and its signaling pathways, suggesting a new mechanism for their therapeutic effects in mood disorders.

This study examines 5-HT2BR expression and binding in AD mouse models and human tissue, finding age-related changes in mice and higher levels in AD patients.

This study shows that SORL1 haploinsufficiency in pigs mimics early AD biomarker changes without neurodegeneration, supporting its role as a causal gene in Alzheimer's disease.

This study shows that tau pathology develops spontaneously in APPswe/PS1ΔE9 mice, demonstrating that amyloidosis is necessary and sufficient to drive tauopathy in familial AD models.