T cell circuits that sense antigen density with an ultrasensitive threshold
Rogelio Antonio Hernández-López, Wei Yu, Katelyn A. Cabral, Olivia A. Creasey, Maria del Pilar Lopez Pazmino, Yurie Tonai, Arsenia De Guzman, Anna R. Mäkelä, Kalle Saksela, Zev J. Gartner, Wendell A. Lim
This paper engineers T cells with a two-step positive feedback circuit to kill target cells based on an ultrasensitive antigen density threshold.
Science · Feb 25, 2021Peer-reviewedSynthetic Biology